The University of Alabama at Birmingham (UAB), Department of Biochemistry and Molecular Genetics is seeking a Researcher IV. The Bedwell lab seeks to understand the mechanism and regulation of translation, the process by which mRNAs are decoded into proteins. Research in the lab combines knowledge and techniques from multiple disciplines, including biochemistry, genetics, molecular biology, cell biology, and bioinformatics to perform both basic and translational research.

General Responsibilities

Working with a high degree of independence:

• To oversee projects within the laboratory.
• To assume responsibility for the day-to-day operation of lab activities.
• To collect, enter, summarize, analyze, and interpret data.
• To contribute significantly to the planning/design of studies.
• To help develop long or short-term goals.

Key Duties & Responsibilities

1. Maintains a large mouse core facility, including breeding, weaning, and genotyping (the core facility provides mice to cystic fibrosis researchers).
2. Maintains detailed mouse core documentation.
3. Performs molecular biology lab techniques such as DNA isolation and PCR.
4. Manages the maintenance of multiple mouse strains according to approved IACUC protocols. Documents breeders and offspring.
5. Generates working chemical solutions/reagents for various assays (buffers, agarose, etc.). Collects tail snips and isolate DNA for genotyping using PCR.
6. Maintains detailed and accurate hard copy and database records of the mouse colony.
7. Assists with other procedures as needed to characterize or treat mice.
8. Administration of therapies to mice.
9. Perfusion of mice.
10. Harvesting of mouse tissues for various CFTR assays.
11. RNA isolation from mouse tissues, quantitative PCR, or digital PCR to genotype mice, examine gene expression, or determine gene copy number.
12. Performs other duties as assigned.

Annual Salary Range $47,486.40 - $66,243.00

• Doctorate in a related field
• OR Master's degree in a related field and two (2) years of related experience
• OR Bachelor’s degree in related field and four (4) years of related experience
• OR Associate's degree in related field and six (6) years of related experience

Work experience may NOT substitute for education requirement.

Preferences

• Degree in biology, chemistry, microbiology, biochemistry, genetics, molecular biology, cell biology, bioinformatics, or a related field.
• Previous research lab experience.

Key Skills

• Strong attention to detail.
• Clear and effective verbal and written communication.
• Ability to document and keep a standard lab notebook.
• Ability to follow directions and established lab protocols.
• Critical thinking
• Organization
• Able to ask questions and seek help when needed.
• Accountability